Interleukin-5 mRNA in Mucosal Bronchial Biopsies from Asthmatic Subjects
نویسندگان
چکیده
منابع مشابه
Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma.
We have attempted to identify mRNA for IL-5 in endobronchial mucosal biopsies from asthmatics and controls, using the technique of in situ hybridization. Bronchial biopsies were obtained from 10 asthmatics and 9 nonatopic normal controls. A radio-labeled cRNA probe was prepared from an IL-5 cDNA and hybridized to permeabilized sections. These were washed extensively before processing for autora...
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Corresponding Author: Clive P. Page, Ph.D Kings College London Sackler Institute of Pulmonary Pharmacology 5 floor, Hodgkin Building, Guys Campus, London, U.K., SE1 1UL Tel: +44 (0)207 8486096 Fax: +44 (0)207 8486097 Email: [email protected] Funded by a grant from GlaxoSmithKline, Stevenage, United Kingdom. Word count: 4741 . Published on October 24, 2007 as doi: 10.1183/09031936.00003707 ...
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BACKGROUND Subjects with allergic asthma develop isolated late asthmatic reactions after inhalation of allergen-derived T cell peptides. Animal experiments have shown that airway hyperresponsiveness (AHR) is CD4+ cell-dependent. It is hypothesised that peptide inhalation produces increases in non-specific AHR and a T cell-dominant bronchial mucosal inflammatory response. METHODS Bronchoscopy,...
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The effect of hypothyroidism on non-specific bronchial reactivity was studied in 11 patients without pulmonary disease (mean age 40 (SD 13) years) who had had a total thyroidectomy and radioiodine treatment for thyroid cancer 41 (36) months before the study. All patients when mildly hyperthyroid while having long term thyroxine replacement treatment and once when hypothyroid two weeks after sto...
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BACKGROUND Attention has recently been focused on the basal cells of the tracheobronchial epithelium as the mechanism of anchorage of the tall columnar cells, which themselves do not appear to form hemidesmosomes with the basement membrane of the epithelium. Residual basal cells have been described as remaining attached to the basement membrane after epithelial denudation. This led this group t...
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ژورنال
عنوان ژورنال: International Archives of Allergy and Immunology
سال: 1991
ISSN: 1018-2438,1423-0097
DOI: 10.1159/000235353